{"id":16163,"date":"2025-07-21T11:13:50Z","date_gmt":"2025-07-21T09:13:50Z","guid":{"rendered":"https:\/\/www.omni-biotic.com\/cs-cz\/zanet-mocovych-cest-kdyz-se-e-coli-zdarne-usidli-v-mocovem-mechyri\/"},"modified":"2025-07-31T11:05:29Z","modified_gmt":"2025-07-31T09:05:29Z","slug":"zanet-mocovych-cest-bakterie-e-coli","status":"publish","type":"post","link":"https:\/\/www.omni-biotic.com\/cs-cz\/blog\/zanet-mocovych-cest-bakterie-e-coli\/","title":{"rendered":"Z\u00e1n\u011bt mo\u010dov\u00fdch cest: Kdy\u017e se bakterie E. coli us\u00eddl\u00ed v mo\u010dov\u00e9m m\u011bch\u00fd\u0159i"},"content":{"rendered":"\t\t
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Co je p\u0159\u00ed\u010dinou z\u00e1n\u011btu mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Ve zhruba 80\u202f% p\u0159\u00edpad\u016f<\/strong> je p\u016fvodcem z\u00e1n\u011btu mo\u010dov\u00fdch cest<\/strong> <\/a>bakterie Escherichia coli<\/strong><\/em>, b\u011b\u017en\u011b p\u0159\u00edtomn\u00e1 ve st\u0159evech. P\u0159es kone\u010dn\u00edk se m\u016f\u017ee dostat a\u017e do mo\u010dov\u00fdch cest a zp\u016fsobit bolestiv\u00e9 p\u0159\u00edznaky, jako je p\u00e1len\u00ed p\u0159i mo\u010den\u00ed a \u010dast\u00e9 nutk\u00e1n\u00ed na toaletu.<\/p>

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\u017deny<\/strong> trp\u00ed z\u00e1n\u011btem mo\u010dov\u00fdch cest a\u017e 50kr\u00e1t \u010dast\u011bji ne\u017e mu\u017ei<\/strong>, hlavn\u011b kv\u016fli krat\u0161\u00ed mo\u010dov\u00e9 trubici a bl\u00edzkosti kone\u010dn\u00edku a mezi dal\u0161\u00ed rizikov\u00e9 faktory pat\u0159\u00ed n\u00edzk\u00fd p\u0159\u00edjem tekutin,<\/strong> zadr\u017eov\u00e1n\u00ed mo\u010di, \u0161patn\u00e1 hygiena<\/strong> (po stolici nebo sexu), prochladnut\u00ed, t\u011bhotenstv\u00ed, cukrovka<\/strong> \u010di hormon\u00e1ln\u00ed zm\u011bny<\/a> <\/strong>(nap\u0159. menopauza).<\/p>

Na z\u00e1n\u011bt mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e mohou poukazovat symptomy jako je p\u00e1len\u00ed a bolest p\u0159i mo\u010den\u00ed, \u010d<\/span>ast\u00e9 nutk\u00e1n\u00ed k mo\u010den\u00ed z<\/span>kalen\u00e1 nebo nep\u0159\u00edjemn\u011b zap\u00e1chaj\u00edc\u00ed mo\u010d, p<\/span>ocit ne\u00fapln\u00e9ho vypr\u00e1zdn\u011bn\u00ed a bolest v podb\u0159i\u0161ku n<\/span>\u011bkdy lehk\u00e1 hore\u010dka nebo celkov\u00e1 \u00fanava nebo b<\/a><\/strong><\/span>olest p\u0159i pohlavn\u00edm styku.<\/span><\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Jak se bakterie E.\u202fcoli udr\u017euj\u00ed v mo\u010dov\u00e9m m\u011bch\u00fd\u0159i?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\"\"V\u011bdci z Basileje a ETH Z\u00fcrich popsali v odborn\u00e9m \u010dasopise Nature Communications<\/em>, jak se bakterie E.\u202fcoli<\/strong> pomoc\u00ed proteinu<\/strong> FimH<\/strong>, kter\u00fd p\u016fsob\u00ed jako \u201elepidlo\u201c, p\u0159ichyt\u00ed na sliznici mo\u010dov\u00e9ho traktu.\u00a0St\u0159evn\u00ed bakterie<\/a><\/strong> vlastn\u00ed dlouh\u00e9, vl\u00e1knovit\u00e9 v\u00fdb\u011b\u017eky, na jejich\u017e konci vytv\u00e1\u0159\u00ed protein FimH mal\u00fd h\u00e1\u010dek,\u00a0 kter\u00fd se p\u0159ichyt\u00e1v\u00e1 na molekuly cukru na povrchu bun\u011bk mo\u010dov\u00e9ho traktu.\u00a0<\/span>Tento mechanismus p\u016fsob\u00ed tak, \u017ee \u010d\u00edm siln\u011bj\u0161\u00ed proud mo\u010di, t\u00edm pevn\u011bji je bakterie p\u0159ichycena,<\/strong> \u010d\u00edm\u017e nem\u016f\u017ee b\u00fdt vyplavena mo\u010d\u00ed.<\/span><\/p>

\u201eD\u00edky kombinaci r\u016fzn\u00fdch biofyzik\u00e1ln\u00edch a biochemick\u00fdch metod jsme byli schopni osv\u011btlit vlastnost FimH se v\u00e1zat s\u00a0doposud nedosa\u017eenou p\u0159esnost\u00ed.\u201c \u0159\u00edk\u00e1 Glockshuber. V\u00a0jejich studii v\u011bdci \u00fapln\u011b poprv\u00e9 dokazuj\u00ed, jak mechanick\u00e9 s\u00edly reguluj\u00ed schopnost FimH se v\u00e1zat. \u201eProtein FimH se skl\u00e1d\u00e1 ze dvou \u010d\u00e1st\u00ed,<\/strong> kde druh\u00e1 \u010d\u00e1st, kter\u00e1 se nev\u00e1\u017ee na cukr ur\u010duje, jak pevn\u011b se ta prvn\u00ed \u010d\u00e1st bude v\u00e1zat na molekuly cukru\u201c, vysv\u011btluje Maier. \u201eKdy\u017e jsou nyn\u00ed ob\u011b \u010d\u00e1sti proudem mo\u010di od sebe odtr\u017eeny, vazebn\u00e9 m\u00edsto pro cukr se uzav\u0159e. Pokud v\u0161ak tahov\u00e9 s\u00edly polev\u00ed, v\u00e1zac\u00ed kapsa se otev\u0159e. Nyn\u00ed se bakterie mohou uvolnit a cestovat mo\u010dovou trubic\u00ed.\u201c<\/strong><\/span><\/p>

Studie ukazuj\u00ed, \u017ee bakterie E.\u202fcoli mohou p\u0159e\u017e\u00edvat uvnit\u0159 bun\u011b\u010dn\u00e9 v\u00fdstelky mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e, kde jsou skryt\u00e9 p\u0159ed antibiotiky<\/a><\/strong> i imunitn\u00edm syst\u00e9mem.<\/strong><\/a> N\u00e1sledn\u011b se mohou znovu aktivovat: nap\u0159\u00edklad ve chv\u00edli, kdy se ve spodn\u00ed \u010d\u00e1sti mo\u010dov\u00e9ho traktu objev\u00ed v\u202fm\u00edrn\u00e9m po\u010dtu bakterie Gardnerella vaginalis<\/strong><\/em><\/a>, k \u010demu\u017e m\u016f\u017ee doj\u00edt t\u0159eba p\u0159i sexu\u00e1ln\u00edm styku. Tato bakterie naru\u0161\u00ed bun\u011b\u010dnou vrstvu m\u011bch\u00fd\u0159e a uvoln\u00ed bakterie E.\u202fcoli, kter\u00e9 se pot\u00e9 mohou mno\u017eit a zp\u016fsobovat z\u00e1n\u011bty.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Jak se nejl\u00e9pe vypo\u0159\u00e1dat se z\u00e1n\u011bty mo\u010dov\u00fdch cest?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Z\u00e1n\u011bty mo\u010dov\u00fdch cest<\/strong> <\/a>jsou druh\u00fdm nej\u010dast\u011bj\u0161\u00edm d\u016fvodem k\u00a0p\u0159edeps\u00e1n\u00ed antibiotik.<\/a><\/strong> Nicm\u00e9n\u011b v\u00a0\u010dasech stoupaj\u00edc\u00ed rezistence se st\u00e1le v\u00edce \u010dast\u011bji poohl\u00ed\u017e\u00edme po alternativn\u00edch l\u00e9\u010debn\u00fdch metod\u00e1ch.<\/strong> P\u0159i prevenci a boji proti infekc\u00edm zp\u016fsoben\u00fdch bakteri\u00ed E. coli by byly vhodnou alternativou l\u00e9\u010diva, kter\u00e1 zabra\u0148uj\u00ed bakteri\u00edm uchytit se v\u00a0mo\u010dov\u00fdch cest\u00e1ch p\u0159es FimH,<\/strong> \u010d\u00edm\u017e bychom se vyhnuli p\u0159ehnan\u00e9mu nasazov\u00e1n\u00ed antibiotik a vzr\u016fstu s\u00a0nimi spojen\u00e9 rezistence.<\/strong> Prof. Ernst z\u00a0farmaceutick\u00e9ho centra Univerzity v\u00a0Basileji se zab\u00fdv\u00e1 ji\u017e roky v\u00fdzkumem FimH-antagonist\u016f. V\u00fdsledky, kter\u00e9 se t\u00fdkaj\u00ed zp\u016fsobu fungov\u00e1n\u00ed FimH tyto snahy jen podpo\u0159\u00ed a budou velk\u00fdm p\u0159\u00ednosem pro identifikaci pat\u0159i\u010dn\u00fdch \u00fa\u010dinn\u00fdch l\u00e1tek.<\/p>

P<\/b><\/span>\u0159i z\u00e1n\u011btu mo\u010dov\u00fdch cest <\/strong>mohou b\u00fdt tak\u00e9 velmi u\u017eite\u010dn\u00e1 probiotika<\/strong>,<\/a> zejm\u00e9na pokud se infekce opakuj\u00ed nebo pokud je pot\u0159eba obnovit p\u0159irozenou mikrofl\u00f3ru <\/a><\/strong>po u\u017e\u00edv\u00e1n\u00ed antibiotik. Probiotika <\/a><\/strong>obnovuj\u00ed p\u0159irozenou mikrofl\u00f3ru pochvy<\/a> a st\u0159ev,<\/strong> kter\u00e1 slou\u017e\u00ed jako prvn\u00ed obrann\u00e1 linie proti patogen\u016fm, v\u010detn\u011b bakterie E. coli <\/em>a z<\/strong>abra\u0148uj\u00ed tak\u00e9 p\u0159emno\u017een\u00ed ne\u017e\u00e1douc\u00edch bakteri\u00ed<\/strong>, jako je nap\u0159\u00edklad Gardnerella vaginalis<\/em>, kter\u00e1 m\u016f\u017ee spustit reaktivaci infekce. Proto\u017ee 70 % na\u0161ich imunitn\u00edch bun\u011bk s\u00eddl\u00ed ve st\u0159evech, <\/strong><\/a>pos\u00edl\u00ed c\u00edlen\u00e9 u\u017e\u00edv\u00e1n\u00ed probiotik tak\u00e9 n\u00e1\u0161<\/span> imunitn\u00ed syst\u00e9m <\/a><\/strong>a prosp\u011b\u0161n\u00e9 laktobacily<\/a><\/strong>obsa\u017een\u00e9 v mnoha probiotick\u00fdch prepar\u00e1tech vytv\u00e1\u0159ej\u00ed v pochv\u011b kysel\u00e9 prost\u0159ed\u00ed,<\/strong> ve kter\u00e9m se \u0161kodliv\u00e9 bakterie h\u016f\u0159e mno\u017e\u00ed.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Z\u00e1n\u011bt mo\u010dov\u00fdch cest pat\u0159\u00ed mezi nej\u010dast\u011bj\u0161\u00ed bakteri\u00e1ln\u00ed infekce, kter\u00e9 postihuj\u00ed \u017eeny i mu\u017ee v\u0161ech v\u011bkov\u00fdch kategori\u00ed. Nej\u010dast\u011bj\u0161\u00edm p\u016fvodcem t\u011bchto infekc\u00ed je bakterie Escherichia coli (E. coli), kter\u00e1 se b\u011b\u017en\u011b vyskytuje ve st\u0159evech, ale p\u0159i p\u0159enosu do mo\u010dov\u00fdch cest m\u016f\u017ee zp\u016fsobit bolestiv\u00e9 a nep\u0159\u00edjemn\u00e9 pot\u00ed\u017ee.<\/p>\n","protected":false},"author":2,"featured_media":19786,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[107,110],"tags":[],"class_list":["post-16163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novinky-ve-vyzkumu","category-zdravi-zeny"],"acf":[],"rank_math":{"og:title":"Z\u00e1n\u011bt mo\u010dov\u00fdch cest: Kdy\u017e se bakterie E. coli us\u00eddl\u00ed v mo\u010dov\u00e9m m\u011bch\u00fd\u0159i","og:desc":"Pokud je z\u00e1n\u011bt mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e zp\u016fsoben bakteri\u00ed E. Coli, m\u016f\u017ee to b\u00fdt velmi nep\u0159\u00edjemn\u00e9, nebo\u0165 ta se z mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e \u010dasto nechce hnout.","og:url":"https:\/\/www.omni-biotic.com\/cs-cz\/blog\/zanet-mocovych-cest-bakterie-e-coli\/","og:locale":"cs_CZ","og:image":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-content\/uploads\/sites\/8\/2022\/01\/thumbnail_large-15.webp","og:image:width":"550","og:image:height":"309"},"additional_data":{"thumbnail":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-content\/uploads\/sites\/8\/2022\/01\/thumbnail_large-15.webp"},"blog_info":{"country":"cs-cz"},"_links":{"self":[{"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/posts\/16163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/comments?post=16163"}],"version-history":[{"count":7,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/posts\/16163\/revisions"}],"predecessor-version":[{"id":19793,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/posts\/16163\/revisions\/19793"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/media\/19786"}],"wp:attachment":[{"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/media?parent=16163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/categories?post=16163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/cs-cz\/wp-json\/wp\/v2\/tags?post=16163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}