{"id":21670,"date":"2024-03-20T14:23:20Z","date_gmt":"2024-03-20T13:23:20Z","guid":{"rendered":"https:\/\/www.omni-biotic.com\/hu-hu\/?p=21670"},"modified":"2024-03-20T14:23:20Z","modified_gmt":"2024-03-20T13:23:20Z","slug":"mi-az-a-spermidin","status":"publish","type":"post","link":"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/mi-az-a-spermidin\/","title":{"rendered":"Spermidin \u2013 A fiatals\u00e1g k\u00fatja a sejteknek"},"content":{"rendered":"\t\t
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A spermidin a sejtmeg\u00faj\u00edt\u00f3 folyamat, az autof\u00e1gia hat\u00e9kony aktiv\u00e1torak\u00e9nt a „fiatals\u00e1g k\u00fatj\u00e1nak tekinthet\u0151. <\/em>A mikrot\u00e1panyagot, amely k\u00e9miailag a poliaminok k\u00f6z\u00e9 tartozik, a szervezetben a b\u00e9lbakt\u00e9riumok termelik.<\/em> A spermidin azonban a t\u00e1pl\u00e1l\u00e9kkal is felsz\u00edv\u00f3dhat.<\/em> Tanulm\u00e1nyok azt mutatj\u00e1k, hogy a k\u00edv\u00fclr\u0151l bevitt spermidin \u00e9s a szervezet saj\u00e1t mikrobiomj\u00e1b\u00f3l sz\u00e1rmaz\u00f3 spermidin hat\u00e1sa kieg\u00e9sz\u00edti egym\u00e1st.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Mi az a spermidin?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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K\u00e9miai \u00e9rtelemben ez a mikrot\u00e1panyag a poliaminok<\/strong><\/b> k\u00f6z\u00e9 tartozik. A spermidin az autof\u00e1gia hat\u00e9kony aktiv\u00e1tor\u00e1nak tekinthet\u0151. Ez egy olyan sejteken bel\u00fcli \u00fajrahasznos\u00edt\u00e1si folyamat, amelynek eredm\u00e9nyek\u00e9ppen az el\u00f6regedett sejtek meg\u00fajulnak<\/strong><\/b>, \u00e9s ez\u00e1ltal helyre\u00e1ll<\/strong><\/b> az aktivit\u00e1suk<\/strong><\/b> [1]. A leg\u00fajabb tanulm\u00e1nyok al\u00e1t\u00e1masztj\u00e1k ezt az elk\u00e9pzel\u00e9st, \u00e9s azt mutatj\u00e1k, hogy ennek a poliaminnak a spermidinben gazdag \u00e9trenddel t\u00f6rt\u00e9n\u0151 fokozott bevitele cs\u00f6kkenti a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gekkel<\/strong><\/b> \u00f6sszef\u00fcgg\u0151 \u00e1ltal\u00e1nos hal\u00e1loz\u00e1si ar\u00e1nyt<\/strong><\/b>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"b\u00e9lbakt\u00e9rium,\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Hol tal\u00e1lhat\u00f3 a spermidin?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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A szervezet saj\u00e1t spermidin-termel\u00e9s\u00e9n<\/strong><\/b> k\u00edv\u00fcl a spermidinben gazdag \u00e9telek<\/strong><\/b> \u00e9s a b\u00e9lmikrobiom<\/a> tekinthet\u0151 a legfontosabb forr\u00e1snak. Az olyan poliaminok, mint a spermidin, mindenf\u00e9le \u00e9lelmiszerben nagy koncentr\u00e1ci\u00f3ban megtal\u00e1lhat\u00f3k. A b\u00fazacs\u00edra<\/strong><\/b> j\u00f3l ismert n\u00f6v\u00e9nyi forr\u00e1s<\/strong><\/b>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Jelenleg nincsenek hivatalos aj\u00e1nl\u00e1sok a spermidin napi bevitel\u00e9re vonatkoz\u00f3an, de klinikai vizsg\u00e1latok szerint napi 1-6 mg optim\u00e1lis kieg\u00e9sz\u00edt\u00e9s [2]. Az \u00e9letkor<\/strong><\/b> el\u0151rehaladt\u00e1val a szervezet egyre kevesebb spermidint termel saj\u00e1t maga [3], ez\u00e9rt van \u00e9rtelme<\/strong><\/b> t\u00e1pl\u00e1l\u00e9k-kieg\u00e9sz\u00edt\u0151<\/strong><\/b> form\u00e1j\u00e1ban szedni<\/strong><\/b>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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A spermidin felsz\u00edv\u00f3d\u00e1sa a szervezetben<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Az \u00e9lelmiszerrel vagy t\u00e1pl\u00e1l\u00e9k-kieg\u00e9sz\u00edt\u0151kkel bevitt spermidin gyorsan felsz\u00edv\u00f3dik a b\u00e9lben, \u00edgy a poliaminok nagy r\u00e9sze m\u00e1r r\u00f6viddel az \u00e9tkez\u00e9s ut\u00e1n elt\u0171nik a b\u00e9lb\u0151l. A molekul\u00e1ris mechanizmus, azaz a k\u00fcls\u0151leg bevitt poliaminok b\u00e9lb\u0151l a v\u00e9rbe val\u00f3 felsz\u00edv\u00f3d\u00e1s\u00e1nak pontos m\u00f3dja m\u00e9g nem tiszt\u00e1zott egy\u00e9rtelm\u0171en. Felt\u00e9telezhet\u0151, hogy a v\u00e9konyb\u00e9l els\u0151 szakasz\u00e1b\u00f3l, a nyomb\u00e9lb\u0151l passz\u00edv diff\u00fazi\u00f3val jutnak a szervezetbe.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Az alternat\u00edv megk\u00f6zel\u00edt\u00e9sek felt\u00e9telezik, hogy a poliaminokat a b\u00e9lny\u00e1lkah\u00e1rtya k\u00fcl\u00f6nb\u00f6z\u0151 h\u00e1msejtjei egy szigor\u00faan szab\u00e1lyozott akt\u00edv transzportfolyamat r\u00e9v\u00e9n veszik fel [4], vagy a felv\u00e9tel \u00fagynevezett endocit\u00f3zis \u00fatj\u00e1n t\u00f6rt\u00e9nik – azaz a sejtmembr\u00e1n azon r\u00e9sz\u00e9nek invagin\u00e1ci\u00f3ja r\u00e9v\u00e9n, amelyhez a spermidin hozz\u00e1tapadt.<\/p>

Ezek a megk\u00f6zel\u00edt\u00e9sek arra utalnak, hogy a spermidin szervezetbe t\u00f6rt\u00e9n\u0151 felv\u00e9tel\u00e9ben sejtspecifikus mechanizmusok j\u00e1tszanak szerepet, amelyeket m\u00e9g r\u00e9szletesebben le kell \u00edrni.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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A b\u00e9lbakt\u00e9riumok fontos spermidin-termel\u0151k<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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A b\u00e9lbakt\u00e9riumok<\/a><\/strong> \u00e1ltal<\/strong><\/b> termelt<\/strong><\/b> spermidin szint\u00e9n ugyanezen a<\/strong><\/b> helyen sz\u00edv\u00f3dik fel<\/strong><\/b> a szervezetbe. A mikrobiom<\/a><\/strong> sejtes mechanizmusai szab\u00e1lyozz\u00e1k a poliamin termel\u00e9s\u00e9t [5]. A b\u00e9lbakt\u00e9riumok \u00e1ltal termelt, autof\u00e1gi\u00e1t kiv\u00e1lt\u00f3 spermidin egy k\u00eds\u00e9rletsorozatban k\u00e9pes volt cs\u00f6kkenteni<\/strong><\/b> a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek<\/strong><\/b> kock\u00e1zat\u00e1t<\/strong><\/b> egerekn\u00e9l.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Ezek a j\u00f3t\u00e9kony bakt\u00e9riumok n\u00f6velhetik a putreszcin, a spermidin prekurzor\u00e1nak termel\u00e9s\u00e9t a b\u00e9lben. Egy vizsg\u00e1lat azt is kimutatta, hogy azokn\u00e1l az emberekn\u00e9l, akik poliamin-termel\u0151 mikrob\u00e1kat tartalmaz\u00f3 joghurtot ettek, javult az endothelfunkci\u00f3 (megjegyz\u00e9s: az endothel a v\u00e9r- \u00e9s nyirokerek bels\u0151 felsz\u00edn\u00e9n l\u00e9v\u0151 sejtr\u00e9teg). A szerz\u0151k arra a k\u00f6vetkeztet\u00e9sre jutottak, hogy a poliamin-termel\u0151 bakt\u00e9riumok fogyaszt\u00e1sa cs\u00f6kkenti<\/strong><\/b> az \u00e9relmeszesed\u00e9s<\/strong><\/b> kock\u00e1zat\u00e1t<\/strong><\/b> [1].<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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A spermidinnel d\u00fas\u00edtott t\u00e1pl\u00e1l\u00e9kot fogyaszt\u00f3 egerekn\u00e9l az \u00f6reged\u00e9s jelei jelent\u0151sen cs\u00f6kkentek<\/strong><\/b> a legmagasabb koncentr\u00e1ci\u00f3j\u00fa csoportban [6].<\/p>

M\u00e1s egereket olyan probiotikus bakt\u00e9riumokkal<\/a><\/strong> kezeltek, amelyek k\u00e9pesek poliaminokat termelni. Az ell\u00e1tott b\u00e9lbakt\u00e9riumok poliamin-ell\u00e1t\u00e1sa a kr\u00f3nikus gyullad\u00e1s<\/strong><\/b> jeleinek egy\u00e9rtelm\u0171 cs\u00f6kken\u00e9s\u00e9hez<\/strong><\/b> \u00e9s az \u00e1llatok \u00e9let\u00e9nek hosszabbod\u00e1s\u00e1hoz<\/strong><\/b> is vezetett [7].<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Forr\u00e1sok:<\/strong>
[1] Matsumoto, Mitsuharu et al. \u201cEndothelial Function is improved by Inducing Microbial Polyamine Production in the Gut: A Randomized Placebo-Controlled Trial.\u201d Nutrients vol. 11,5 1188. 27 May. 2019, doi:10.3390\/nu11051188<\/p>


[2] Schwarz, Claudia et al. \u201cSafety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.\u201d Aging vol. 10,1 (2018): 19-33. doi:10.18632\/aging.101354[3] Mu\u00f1oz-Esparza, Latorre-Moratalla et al. \u201c Polyamines in Food\u201d Frontiers in Nutrition vol. 6 (2019): 108. doi:10.3389\/fnut.2019.00108<\/p>


[4] Milovic, V. \u201cPolyamines in the gut lumen: bioavailability and biodistribution.\u201d European journal of gastroenterology & hepatology vol. 13,9 (2001): 1021-5. doi:10.1097\/00042737-200109000-00004<\/p>


[5] Thomas, T, and T J Thomas. \u201cPolyamines in cell growth and cell death: molecular mechanisms and therapeutic applications.\u201d Cellular and molecular life sciences : CMLS vol. 58,2 (2001): 244-58. doi:10.1007\/PL00000852<\/p>


[6] Soda, Kuniyasu et al. \u201cPolyamine-rich food decreases age-associated pathology and mortality in aged mice.\u201d Experimental gerontology vol. 44,11 (2009): 727-32. doi:10.1016\/j.exger.2009.08.013<\/p>


[7] Matsumoto, Mitsuharu et al. \u201cLongevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production.\u201d PloS one vol. 6,8 (2011): e23652. doi:10.1371\/journal.pone.0023652<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

A spermidin a sejtmeg\u00faj\u00edt\u00f3 folyamat, az autof\u00e1gia hat\u00e9kony aktiv\u00e1torak\u00e9nt a „fiatals\u00e1g k\u00fatj\u00e1nak tekinthet\u0151. A mikrot\u00e1panyagot, amely k\u00e9miailag a poliaminok k\u00f6z\u00e9 tartozik, a szervezetben a b\u00e9lbakt\u00e9riumok termelik. A spermidin azonban a t\u00e1pl\u00e1l\u00e9kkal is felsz\u00edv\u00f3dhat. Tanulm\u00e1nyok azt mutatj\u00e1k, hogy a k\u00edv\u00fclr\u0151l bevitt spermidin \u00e9s a szervezet saj\u00e1t mikrobiomj\u00e1b\u00f3l sz\u00e1rmaz\u00f3 spermidin hat\u00e1sa kieg\u00e9sz\u00edti egym\u00e1st. Mi az a spermidin? […]<\/p>\n","protected":false},"author":19,"featured_media":21689,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[109],"tags":[],"class_list":["post-21670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ujdonsagok-a-kutatasban"],"acf":[],"rank_math":{"og:title":"Spermidin \u2013 A fiatals\u00e1g k\u00fatja a sejteknek - OMNi-BiOTiC\u00ae","og:desc":"Mi is az a spermidin? A sejtmeg\u00faj\u00edt\u00f3 folyamat, az autof\u00e1gia hat\u00e9kony aktiv\u00e1torak\u00e9nt a fiatals\u00e1g k\u00fatj\u00e1nak tekinthet\u0151.","og:url":"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/mi-az-a-spermidin\/","og:locale":"hu_HU","og:image":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/03\/spermidin.jpg","og:image:width":"768","og:image:height":"512"},"additional_data":{"thumbnail":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/03\/spermidin.jpg"},"blog_info":{"country":"hu-hu"},"_links":{"self":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts\/21670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/comments?post=21670"}],"version-history":[{"count":7,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts\/21670\/revisions"}],"predecessor-version":[{"id":21710,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts\/21670\/revisions\/21710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/media\/21689"}],"wp:attachment":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/media?parent=21670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/categories?post=21670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/tags?post=21670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}