{"id":22016,"date":"2024-04-11T12:42:20Z","date_gmt":"2024-04-11T10:42:20Z","guid":{"rendered":"https:\/\/www.omni-biotic.com\/hu-hu\/?p=22016"},"modified":"2024-04-11T12:54:26Z","modified_gmt":"2024-04-11T10:54:26Z","slug":"reumatoid-artritisz","status":"publish","type":"post","link":"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/reumatoid-artritisz\/","title":{"rendered":"Reumatoid artritisz, mikrobiom \u00e9s probiotikumok"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22016\" class=\"elementor elementor-22016\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e51496f obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"e51496f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1868ba6 elementor-widget elementor-widget-heading\" data-id=\"1868ba6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Reumatoid artritisz, a mikrobiom \u00e9s probiotikumok<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-83f9b9a obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"83f9b9a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-272c6f5 elementor-widget elementor-widget-text-editor\" data-id=\"272c6f5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/a-belrendszer-egeszsege\/a-bel-az-egeszseg-kozpontja\/belmikrobiom\/\"><strong>mikrobiom<\/strong> <\/a>a r\u00f6vid sz\u00e9nl\u00e1nc\u00fa zs\u00edrsavak (SCFA-k: butir\u00e1t, propion\u00e1t \u00e9s acet\u00e1t) termel\u00e9s\u00e9n kereszt\u00fcl l\u00e9p k\u00f6lcs\u00f6nhat\u00e1sba az <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/a-belrendszer-egeszsege\/a-bel-hataskore\/az-immunrendszer\/\"><strong>immunrendszerrel<\/strong><\/a>. A <strong>butir\u00e1t<\/strong> kedvez\u0151en hat az immuntoleranci\u00e1ra, m\u00edg az <strong>acet\u00e1t<\/strong> els\u0151sorban a gyullad\u00e1sos immunv\u00e1laszt serkenti a pro-inflammatorikus citokinek (az immunsejtek k\u00f6z\u00f6tti kommunik\u00e1ci\u00f3t \u00e9s az immunv\u00e1lasz ir\u00e1ny\u00edt\u00e1s\u00e1t lehet\u0151v\u00e9 tev\u0151 feh\u00e9rj\u00e9k) jelenl\u00e9t\u00e9ben.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-12edce0 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"12edce0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e149888 elementor-widget elementor-widget-text-editor\" data-id=\"e149888\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Reumatoid artritisz sor\u00e1n a mikrobiom \u00f6sszet\u00e9tele az acet\u00e1ttermel\u0151k jav\u00e1ra v\u00e1ltozik.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1823389 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"1823389\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47e6d61 elementor-widget elementor-widget-text-editor\" data-id=\"47e6d61\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/a-belrendszer-egeszsege\/a-bel-az-egeszseg-kozpontja\/probiotikum\/\"><strong>Probiotikumokkal<\/strong> <\/a>n\u00f6velhet\u0151 a butir\u00e1ttermel\u0151 bakt\u00e9riumok koloniz\u00e1ci\u00f3ja.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-338b349 elementor-widget elementor-widget-image\" data-id=\"338b349\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"534\" src=\"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_mikrobiom_omni_biotic.jpg\" class=\"attachment-large size-large wp-image-22023\" alt=\"Reumatoid artritisz, a mikrobiom, probiotikum, omni-biotic\" srcset=\"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_mikrobiom_omni_biotic.jpg 1024w, https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_mikrobiom_omni_biotic-300x200.jpg 300w, https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_mikrobiom_omni_biotic-768x512.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7e659cd obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"7e659cd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6915794 elementor-widget elementor-widget-heading\" data-id=\"6915794\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">A mikrobiom n\u00e9h\u00e1ny f\u0151 jellemz\u0151je<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9b1b1d elementor-widget elementor-widget-text-editor\" data-id=\"e9b1b1d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/a-belrendszer-egeszsege\/a-bel-az-egeszseg-kozpontja\/belflora\/\"><strong>b\u00e9lfl\u00f3ra<\/strong> <\/a>az emberi fajjal egy\u00fctt fejl\u0151d\u00f6tt ki, \u00e9s l\u00e9ptek szimbi\u00f3zisba. A <strong>mikrobiom diverzit\u00e1s\u00e1t<\/strong> \u00e9s \u00f6sszet\u00e9tel\u00e9t r\u00e9szben a gazdaszervezet genetikai \u00e9s \u00e9trendi t\u00e9nyez\u0151i hat\u00e1rozz\u00e1k meg.[1]<\/p><p>Az ut\u00f3bbi \u00e9vekben egyre vil\u00e1gosabb\u00e1 v\u00e1lt, hogy a <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/belbakteriumok-fajtai-es-szerepe\/\"><strong>b\u00e9lbakt\u00e9riumok<\/strong> <\/a>anyagcsere-term\u00e9keiken &#8211; r\u00f6vid sz\u00e9nl\u00e1nc\u00fa zs\u00edrsavakon (SCFA) &#8211; kereszt\u00fcl k\u00f6zvetett k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9pnek a gazdaszervezettel, \u00e9s a b\u00e9lh\u00e1msejtek kiegyens\u00falyozott mikrobiomban stimul\u00e1lj\u00e1k a b\u00e9lrendszeri h\u00e1msejteket, hogy fenntarts\u00e1k a gyomor-b\u00e9l traktusban a kiegyens\u00falyozott velesz\u00fcletett \u00e9s szerzett immunv\u00e1laszt. <span style=\"color: var( --e-global-color-text );text-align: var(--text-align);background-color: inherit;font-family: var( --e-global-typography-text-font-family ), -apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif;font-size: var( --e-global-typography-text-font-size );font-style: var( --e-global-typography-text-font-style );font-weight: var( --e-global-typography-text-font-weight );letter-spacing: var( --e-global-typography-text-letter-spacing );text-transform: var( --e-global-typography-text-text-transform )\">Az SCFA-k t\u00f6bbs\u00e9ge a vastagb\u00e9lben termel\u0151dik, amelyek k\u00f6z\u00fcl a legfontosabb \u00e9s legt\u00f6bbet vizsg\u00e1lt a <strong>butir\u00e1t<\/strong>, a <strong>propion\u00e1t<\/strong> \u00e9s az <strong>acet\u00e1t<\/strong>.\u00a0<\/span><\/p><p>A <strong>butir\u00e1tr\u00f3l<\/strong> ismert, hogy g\u00e1tolja az NF-\u03baB gyullad\u00e1skelt\u0151 jel\u00e1tviteli \u00fatvonalat, \u00e9s stimul\u00e1lja a szab\u00e1lyoz\u00f3 T-limfocit\u00e1kat \u00e9s az effektor T-sejteket (immunhomeoszt\u00e1zis). Sz\u00fcks\u00e9ges tov\u00e1bb\u00e1 a h\u00e1msejtek prolifer\u00e1ci\u00f3j\u00e1hoz (mint energiaforr\u00e1s) \u00e9s a b\u00e9lh\u00e1mr\u00e9teg integrit\u00e1s\u00e1nak fenntart\u00e1s\u00e1hoz sz\u00fcks\u00e9ges jav\u00edt\u00f3 mechanizmusokhoz. Az SCFA-k a hiszton-m\u00f3dos\u00edt\u00f3 enzimeken (hiszton-deacetil\u00e1zok, HDAC-ok) kereszt\u00fcl a sejtek \u00e1t\u00edr\u00e1s\u00e1t \u00e9s feh\u00e9rjefunkci\u00f3j\u00e1t is befoly\u00e1solhatj\u00e1k.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-811a254 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"811a254\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9355cba elementor-widget elementor-widget-text-editor\" data-id=\"9355cba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Az <strong>acet\u00e1t<\/strong> a butir\u00e1thoz hasonl\u00f3 hat\u00e1st fejt ki, azzal a fontos k\u00fcl\u00f6nbs\u00e9ggel, hogy proinflammatorikus gyullad\u00e1sos k\u00f6rnyezetben els\u0151sorban a T effektor sejtek (proinflamm\u00e1ci\u00f3) stimul\u00e1l\u00f3dnak, a szab\u00e1lyoz\u00f3 T sejtek (immuntolerancia) nem. Az autoimmun \u00e9s autoinflammatorikus betegs\u00e9gekben, p\u00e9ld\u00e1ul reumatoid artritiszben (RA), spondyloartritiszben (SpA) \u00e9s psoriaticus artritiszben (PsA) szenved\u0151 betegekn\u00e9l diszbi\u00f3zis \u00e9s a b\u00e9lmikrobiom cs\u00f6kkent diverzit\u00e1sa figyelhet\u0151 meg.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57e9726 elementor-widget elementor-widget-heading\" data-id=\"57e9726\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Reumatoid artritisz (RA)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6fdd92e obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"6fdd92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f59df44 elementor-widget elementor-widget-text-editor\" data-id=\"f59df44\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A genetikai hajlam szerepet j\u00e1tszik az Reumatoid artritisz kialakul\u00e1s\u00e1ban, b\u00e1r az ut\u00f3bbi \u00e9vekben kimutatt\u00e1k, hogy a k\u00f6rnyezeti hat\u00e1sok, p\u00e9ld\u00e1ul a <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/a-dohanyzas-gyulladasos-folyamatokat-valt-ki-a-belekben\/\"><strong>doh\u00e1nyz\u00e1s<\/strong><\/a>, a fert\u0151z\u00e9sek \u00e9s a mikrobiom is d\u00f6nt\u0151 szerepet j\u00e1tszik a megbeteged\u00e9sben.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f1c3357 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"f1c3357\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-21487ae elementor-widget elementor-widget-image\" data-id=\"21487ae\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"465\" src=\"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_mikrobiom_belflora_probiotikum.png\" class=\"attachment-large size-large wp-image-22024\" alt=\"\" srcset=\"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_mikrobiom_belflora_probiotikum.png 640w, https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_mikrobiom_belflora_probiotikum-300x218.png 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34a3ab6 elementor-widget elementor-widget-text-editor\" data-id=\"34a3ab6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A <strong>doh\u00e1nyz\u00e1s<\/strong> a feh\u00e9rj\u00e9k fokozott citrullin\u00e1ci\u00f3j\u00e1hoz vezet a peptidil-arginin-deimin\u00e1zon (PAD) kereszt\u00fcl, ami megmagyar\u00e1zhatja az anticitrullin\u00e1lt peptid antitestek (ACPA) el\u0151fordul\u00e1s\u00e1t ak\u00e1r 10 \u00e9vvel a betegs\u00e9g kialakul\u00e1sa el\u0151tt. A doh\u00e1nyz\u00e1s szint\u00e9n \u00f6sszef\u00fcgg a fog\u00e1gybetegs\u00e9ggel (parodontitis<strong>)<\/strong>\u00a0amelyet a <em>Porphyromonas gingivalis<\/em> okoz. Az RA-betegekn\u00e9l fokozott a parodontitis \u00e9s a <em>P. gingivalis<\/em> sz\u00e1j\u00fcregi koloniz\u00e1ci\u00f3 el\u0151fordul\u00e1sa. [3]<\/p><p>Epidemiol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k a<em> P. gingivalis<\/em> antitestek fokozott el\u0151fordul\u00e1s\u00e1t RA-betegekn\u00e9l, b\u00e1r a fert\u0151z\u00e9ses kiv\u00e1lt\u00f3 okra vonatkoz\u00f3 sz\u00e1mos hipot\u00e9zis ellen\u00e9re eddig nem tal\u00e1ltak k\u00f6zvetlen bakteri\u00e1lis bizony\u00edt\u00e9kot. A <em>P. gingivalis<\/em> az egyetlen ismert komens\u00e1lis, amely expressz\u00e1lja a PAD enzimet, \u00e9s \u00edgy citrullin\u00e1lja az emberi feh\u00e9rj\u00e9ket.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0ffa2a9 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"0ffa2a9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f085ac elementor-widget elementor-widget-text-editor\" data-id=\"1f085ac\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A <strong>gyomor-b\u00e9l traktusban<\/strong> k\u00fcl\u00f6n\u00f6sen jelent\u0151snek t\u0171nik a <em>Bacteroidetes<\/em> popul\u00e1ci\u00f3 cs\u00f6kken\u00e9se \u00e9s a <em>Prevotella copri<\/em> fokozott el\u0151fordul\u00e1sa (75 %, a norm\u00e1l popul\u00e1ci\u00f3 25 %). A <em>Faecalibacterium<\/em>, az egyik leggyakoribb fiziol\u00f3gi\u00e1s b\u00e9lbakt\u00e9rium \u00e9s <strong>butir\u00e1ttermel\u0151<\/strong>, szint\u00e9n cs\u00f6kkent, \u00e9s a mikrobiom eltol\u00f3dott az acet\u00e1ttermel\u0151k fel\u00e9. \u00dagy t\u0171nik, hogy a mikrobiom cs\u00f6kkent diverzit\u00e1s\u00e1t els\u0151sorban a betegs\u00e9g id\u0151tartama \u00e9s az autoantitestek jelenl\u00e9te hat\u00e1rozza meg. [4]<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3d69d2a obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"3d69d2a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6647363 elementor-widget elementor-widget-text-editor\" data-id=\"6647363\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A Zhang \u00e9s munkat\u00e1rsai \u00e1ltal \u00fajonnan diagnosztiz\u00e1lt \u00e9s kor\u00e1bban nem kezelt RA-s betegekkel v\u00e9gzett vizsg\u00e1latban az eg\u00e9szs\u00e9ges kontrollcsoport egy r\u00e9sze RA-s betegek k\u00f6zeli hozz\u00e1tartoz\u00f3ib\u00f3l \u00e1llt. Ezeknek a betegeknek a mikrobi\u00e1lis \u00f6sszet\u00e9tele azonban k\u00f6zelebb \u00e1llt a t\u00f6bbi eg\u00e9szs\u00e9ges kontrollcsoporthoz, mint a rokon RA-betegek\u00e9hez.\u00a0 Felt\u00e9telezhet\u0151, hogy a genetikai, \u00e9trendi \u00e9s k\u00f6rnyezeti hat\u00e1sok a jelek szerint kisebb szerepet j\u00e1tszanak a mikrobiom v\u00e1ltoz\u00e1s\u00e1ban. [5]<\/p><p>Ez a vizsg\u00e1lat azt is kimutatta, hogy az immunmodul\u00e1ci\u00f3 megkezd\u00e9se \u00e9s ez\u00e1ltal a betegs\u00e9g aktivit\u00e1s\u00e1nak cs\u00f6kken\u00e9se a kezel\u00e9sben nem r\u00e9szes\u00fcl\u0151 betegekn\u00e9l a mikrobi\u00e1lis fl\u00f3ra rekompenz\u00e1ci\u00f3j\u00e1hoz vezetett.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-474d204 elementor-widget elementor-widget-heading\" data-id=\"474d204\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Probiotikumok alkalmaz\u00e1sa el\u0151ny\u00f6s?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c151081 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"c151081\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f64b48 elementor-widget elementor-widget-text-editor\" data-id=\"6f64b48\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Reum\u00e1s \u00edz\u00fcleti gyullad\u00e1s eset\u00e9n n\u00e9h\u00e1ny vizsg\u00e1lat sor\u00e1n megpr\u00f3b\u00e1lt\u00e1k kimutatni a gyullad\u00e1s aktivit\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9t sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/a-belrendszer-egeszsege\/a-bel-az-egeszseg-kozpontja\/probiotikum\/\"><strong>probiotikum<\/strong> <\/a>adagol\u00e1s\u00e1val. Erre a c\u00e9lra a <em>Lactobacillus caseit<\/em> alkalmazt\u00e1k. Az egyik vizsg\u00e1lat a tumor nekr\u00f3zis faktor (TNF) sz\u00e9rumban m\u00e9rt \u00e9rt\u00e9k\u00e9nek jelent\u0151s cs\u00f6kken\u00e9s\u00e9t mutatta ki, de a klinikai param\u00e9terekben nem volt kimutathat\u00f3 v\u00e1ltoz\u00e1s. [6]<\/p><p>Zamainak \u00e9s munkat\u00e1rsainak <em>Lactobacillus rhamnosus<\/em>, <em>L. reuteri<\/em> \u00e9s <em>L. casei<\/em> alkalmaz\u00e1s\u00e1val v\u00e9gzett vizsg\u00e1lat sor\u00e1n n az IL-12 \u00e9s a TNF, valamint a C-reakt\u00edv feh\u00e9rje \u00e9s a klinikai param\u00e9terek jelent\u0151s cs\u00f6kken\u00e9s\u00e9t siker\u00fclt el\u00e9rni. [7] Meg kell azonban eml\u00edteni, hogy a probiotikus ter\u00e1pia ut\u00e1n a betegs\u00e9g aktivit\u00e1s\u00e1nak statisztikailag szignifik\u00e1ns cs\u00f6kken\u00e9se m\u00e9g mindig \u00e1tlagos \u00e9rt\u00e9ket jelentett (a DAS28 4,0-r\u00f3l 3,7-re cs\u00f6kkent).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d646a11 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"d646a11\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b887eb elementor-widget elementor-widget-image\" data-id=\"7b887eb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_omni-biotic.jpg\" class=\"attachment-large size-large wp-image-22037\" alt=\"\" srcset=\"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_omni-biotic.jpg 700w, https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_omni-biotic-300x214.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01e0425 elementor-widget elementor-widget-text-editor\" data-id=\"01e0425\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A probiotikumok alkalmaz\u00e1sa sor\u00e1n a m\u00faltban a t\u00f6bbnyire fakultat\u00edv anaerob probiotikus t\u00f6rzsek nem voltak k\u00e9pesek koloniz\u00e1lni az als\u00f3 t\u00e1pcsatorn\u00e1t.<\/p><p>A leg\u00edg\u00e9retesebb anaerob bakt\u00e9riumok, amelyek ebben az esetben felhaszn\u00e1lhat\u00f3k: <em><a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/akkermansia-muciniphila\/\"><strong>Akkermansia muciniphila<\/strong><\/a>, Bacteroides fragilis, Bacteroides thetaiotaomicron, Faecalibacterium prausnitzii <\/em>\u00e9s <em>Prevotella histicola.<\/em><\/p><ul><li>Az <a href=\"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/akkermansia-muciniphila\/\"><strong>A. muciniphila<\/strong><\/a> nagy mennyis\u00e9g\u0171 SCFA-t termel \u00e9s modul\u00e1lja az immunrendszert;<\/li><li><em>AB. fragilis<\/em> szint\u00e9n pozit\u00edvan befoly\u00e1solja az immunrendszert e betegs\u00e9ggel \u00f6sszef\u00fcgg\u00e9sben;\u00a0<\/li><li>A <em>B. thetaiotaomicron<\/em> befoly\u00e1solja a mikrobiom t\u00f6bbi r\u00e9sz\u00e9nek \u00f6sszet\u00e9tel\u00e9t az\u00e1ltal, hogy cs\u00f6kkenti a patog\u00e9n bakt\u00e9riumokat, p\u00e9ld\u00e1ul a<em> Listeria monocytogenest<\/em>, ami viszont a hasznos b\u00e9lbakt\u00e9riumok sz\u00e1m\u00e1nak n\u00f6veked\u00e9s\u00e9hez vezet.<\/li><li>Az <em>F. prausnitzii<\/em> az egyik legnagyobb <strong>butir\u00e1ttermel\u0151nek<\/strong> sz\u00e1m\u00edt (a hat\u00e1sokr\u00f3l l\u00e1sd fentebb);\u00a0<\/li><li><em>A P. histicola<\/em> el\u0151seg\u00edti a T-sejtek differenci\u00e1l\u00f3d\u00e1s\u00e1t a szab\u00e1lyoz\u00f3 T-sejtek ir\u00e1ny\u00e1ba, \u00e9s el\u0151seg\u00edti az olyan fiziol\u00f3gi\u00e1s b\u00e9lbakt\u00e9riumok, mint a <em>Prevotella<\/em> \u00e9s a <em>Sutterella<\/em>, prolifer\u00e1ci\u00f3j\u00e1t.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7475c63 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"7475c63\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f06fb97 elementor-widget elementor-widget-text-editor\" data-id=\"f06fb97\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Az, hogy a <strong>probiotikumok<\/strong> alkalmaz\u00e1sa milyen m\u00e9rt\u00e9kben j\u00e1tszik majd szerepet az RA kezel\u00e9s\u00e9ben a j\u00f6v\u0151ben, m\u00e9g mindig a folyamatban l\u00e9v\u0151 kutat\u00e1sok t\u00e1rgya. A <strong>probiotikus ter\u00e1pia<\/strong> j\u00f6v\u0151je mindenesetre az egy\u00e9ni mikrobiom-elemz\u00e9sben \u00e9s a probiotikus t\u00f6rzsek szem\u00e9lyre szabott \u00f6sszet\u00e9tel\u00e9ben rejlik, hogy lehet\u0151v\u00e9 v\u00e1ljon a <strong>mikrobiom c\u00e9lzott optimaliz\u00e1l\u00e1sa.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1819335 obcs none e-flex e-con-boxed e-con e-parent\" data-id=\"1819335\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c60143d elementor-widget elementor-widget-text-editor\" data-id=\"c60143d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Forr\u00e1sok:<\/p><p>[1] Ley RE et al, Science 2008; 320(5883):1647-51<br \/>[2] Zhou L et al, Inflamm Bowel Dis 2018; Doi: 10.1093\/ibd\/izy182<br \/>[3] Scher JU et al, Nat Rev Rheumatol. 2011; 7(10):569-578<br \/>[4] Chen J et al, Genome Med 2016; 1-14. DOI: 10.1186\/s13073-016-0299-7<br \/>[5] Zhang X et al, Nat Med 2015; 21(8):1-13<br \/>[6] Alipour B et al, Int J Rheum Dis 2014; 17(5):519-27<br \/>[7] Zamani B et al, In J Rheum Dis 2016; 19(9):869-79<\/p><p>Szerz\u0151: Dr. Andreas Haidmayer, Klinikai Reumatol\u00f3giai \u00e9s Immunol\u00f3giai Oszt\u00e1ly, Belgy\u00f3gy\u00e1szati Tansz\u00e9k, Grazi Orvostudom\u00e1nyi Egyetem<\/p><p>Link (csak n\u00e9met nyelven): https:\/\/www.medmedia.at\/univ-innere-medizin\/das-mikrobiom-probiotika-und-rheumatoide-arthritis\/<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Reumatoid artritisz, a mikrobiom \u00e9s probiotikumok A mikrobiom a r\u00f6vid sz\u00e9nl\u00e1nc\u00fa zs\u00edrsavak (SCFA-k: butir\u00e1t, propion\u00e1t \u00e9s acet\u00e1t) termel\u00e9s\u00e9n kereszt\u00fcl l\u00e9p k\u00f6lcs\u00f6nhat\u00e1sba az immunrendszerrel. A butir\u00e1t kedvez\u0151en hat az immuntoleranci\u00e1ra, m\u00edg az acet\u00e1t els\u0151sorban a gyullad\u00e1sos immunv\u00e1laszt serkenti a pro-inflammatorikus citokinek (az immunsejtek k\u00f6z\u00f6tti kommunik\u00e1ci\u00f3t \u00e9s az immunv\u00e1lasz ir\u00e1ny\u00edt\u00e1s\u00e1t lehet\u0151v\u00e9 tev\u0151 feh\u00e9rj\u00e9k) jelenl\u00e9t\u00e9ben. Reumatoid artritisz sor\u00e1n [&hellip;]<\/p>\n","protected":false},"author":19,"featured_media":22023,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-22016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein"],"acf":[],"rank_math":{"og:title":"Reumatoid artritisz, mikrobiom \u00e9s probiotikumok","og:desc":"Mit\u0151l alakul ki a Reumatoid artritisz? Genetikai hajlam, fert\u0151z\u00e9sek \u00e9s a mikrobiom is d\u00f6nt\u0151 szerepet j\u00e1tszik reum\u00e1s betegs\u00e9g kialakul\u00e1s\u00e1ban","og:url":"https:\/\/www.omni-biotic.com\/hu-hu\/blog\/reumatoid-artritisz\/","og:locale":"hu_HU","og:image":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_mikrobiom_omni_biotic.jpg","og:image:width":"1024","og:image:height":"683"},"additional_data":{"thumbnail":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-content\/uploads\/sites\/7\/2024\/04\/Reumatoid_artritisz_probiotikum_mikrobiom_omni_biotic.jpg"},"blog_info":{"country":"hu-hu"},"_links":{"self":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts\/22016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/comments?post=22016"}],"version-history":[{"count":7,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts\/22016\/revisions"}],"predecessor-version":[{"id":22115,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/posts\/22016\/revisions\/22115"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/media\/22023"}],"wp:attachment":[{"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/media?parent=22016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/categories?post=22016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/hu-hu\/wp-json\/wp\/v2\/tags?post=22016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}