{"id":22044,"date":"2024-01-25T14:29:52Z","date_gmt":"2024-01-25T13:29:52Z","guid":{"rendered":"https:\/\/www.omni-biotic.com\/sk-sk\/?p=22044"},"modified":"2026-01-20T16:37:37Z","modified_gmt":"2026-01-20T15:37:37Z","slug":"plodnost-a-suvislost-s-mikrobiomom","status":"publish","type":"post","link":"https:\/\/www.omni-biotic.com\/sk-sk\/blog\/plodnost-a-suvislost-s-mikrobiomom\/","title":{"rendered":"Plodnos\u0165 a s\u00favislos\u0165 s mikrobi\u00f3mom"},"content":{"rendered":"\t\t
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Bakteri\u00e1lna diverzita v \u010drev\u00e1ch: v\u00fdrazne zn\u00ed\u017een\u00e1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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U pacientok so syndr\u00f3mom polycystick\u00fdch vaje\u010dn\u00edkov (PCOS)<\/strong><\/span><\/a> sa len ned\u00e1vno zistilo, \u017ee rozmanitos\u0165 bakt\u00e9ri\u00ed v \u010drev\u00e1ch<\/strong> je v\u00fdrazne zn\u00ed\u017een\u00e1<\/strong> a \u017ee v nich zost\u00e1va sotva dostatok „dobr\u00fdch“ bakteri\u00e1lnych kme\u0148ov. V prebiehaj\u00facej \u0161t\u00fadii s viacdruhov\u00fdm probiotikom v kombin\u00e1cii s vitam\u00ednom D<\/span><\/a><\/strong> sa teraz analyzuj\u00fa pacientky, aby sa zistilo, ako mo\u017eno pozit\u00edvne cielene ovplyvni\u0165 mikrobi\u00f3m<\/span><\/a><\/strong>.<\/p>

Pribli\u017ene 20-30 % \u017eien na celom svete m\u00e1 genetick\u00fa predispoz\u00edciu k PCOS<\/strong> a postihuje dokonca aj mu\u017eov. Pr\u00edznaky<\/strong> s\u00fa r\u00f4zne. V\u0161eobecne trpia niektor\u00e9 v\u00e4\u010d\u0161\u00edm ochlpen\u00edm<\/strong> na tele so s\u00fa\u010dasn\u00fdm vypad\u00e1van\u00edm vlasov<\/strong> na hlave, zatia\u013e \u010do u in\u00fdch sa objavuj\u00fa poruchy cyklu<\/strong> alebo mal\u00e9 cysty vo vaje\u010dn\u00edkoch<\/strong>. Syndr\u00f3m je definovan\u00fd predov\u0161etk\u00fdm na z\u00e1klade tzv. rotterdamsk\u00fdch krit\u00e9ri\u00ed, pod\u013ea ktor\u00fdch s\u00fa podmienkou diagn\u00f3zy<\/strong> aspo\u0148 2 z t\u00fdchto 3 uveden\u00fdch probl\u00e9mov.<\/p>

Mu\u017esk\u00fd fenotyp \u010dasto vykazuje v\u00fdrazn\u00fd sklon k vypad\u00e1vaniu vlasov a ple\u0161ateniu<\/strong>, ako aj k mastnej pleti<\/strong> a akn\u00e9 v mladom veku.<\/p>

Medzin\u00e1rodn\u00e1 genetick\u00e1 \u0161t\u00fadia<\/strong> na pol mili\u00f3ne \u013eud\u00ed uk\u00e1zala, \u017ee na vzniku<\/strong> tohto syndr\u00f3mu sa podie\u013ea pribli\u017ene 30 g\u00e9nov<\/strong> vr\u00e1tane d\u00f4le\u017eit\u00fdch g\u00e9nov v oblasti metabolizmu<\/strong> inzul\u00ednu<\/strong>. Predpoklad\u00e1 sa, \u017ee zv\u00fd\u0161en\u00e1 hladina inzul\u00ednu a inzul\u00ednov\u00e1 rezistencia, ktor\u00e1 sa vyskytuje pri PCOS<\/strong>, bola kedysi z evolu\u010dn\u00e9ho h\u013eadiska d\u00f4le\u017eit\u00e1, aby bolo mo\u017en\u00e9 \u010do najr\u00fdchlej\u0161ie uskladni\u0165 ve\u013ek\u00e9 mno\u017estvo energie, a tak lep\u0161ie pre\u017ei\u0165 hladomory. Podobne nepravideln\u00fd cyklus \u017eien<\/strong> s PCOS pravdepodobne zabra\u0148oval tehotenstv\u00e1m v r\u00fdchlom slede za sebou, a tak vlastne poskytoval v\u00fdhody pre\u017eitia.<\/p>

PCOS<\/strong> teda nie je choroba ako tak\u00e1, ale evolu\u010dn\u00fd prirodzen\u00fd variant, ktor\u00fd bol v predindustri\u00e1lnych \u010dasoch celkom adapt\u00edvny.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ak\u00e9 formy lie\u010dby s\u00fa k dispoz\u00edcii pri PCOS?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Najbe\u017enej\u0161ou formou lie\u010dby PCOS<\/strong> dnes je „antikoncep\u010dn\u00e1 tabletka“<\/strong><\/span><\/a>. Pod\u00e1vanie Metform\u00ednu<\/strong> (off-label), lieku ur\u010den\u00e9ho na diabetes, predstavuje nehormon\u00e1lnu variantu<\/strong> lie\u010dby PCOS<\/strong> s ur\u010dit\u00fdmi v\u00fdhodami, preto\u017ee ho mo\u017eno pou\u017ei\u0165 aj u mlad\u00fdch a star\u0161\u00edch \u017eien a det\u00ed. Z\u00e1rove\u0148 m\u00e1 aj zn\u00ed\u017euj\u00faci \u00fa\u010dinok na hladinu inzul\u00ednu<\/strong> a \u00fa\u010dinky inzul\u00ednov\u00e9ho rastov\u00e9ho faktora 1 (IGF-1). Av\u0161ak ved\u013eaj\u0161ie \u00fa\u010dinky s\u00fa vysok\u00e9<\/strong> a na rozdiel od „antikoncep\u010dnej tabletky“ men\u00ed Metform\u00edn<\/strong> aj zlo\u017eenie mikrobi\u00f3mu pacientov<\/strong>.<\/p>

Univ.-Prof. Dr. Barbara Obermayer-Pietsch ako prv\u00e1 pou\u017eila probiotik\u00e1<\/strong> <\/span><\/a>v kombin\u00e1cii s di\u00e9tou s n\u00edzkym obsahom sacharidov<\/strong> ako \u00faplne nov\u00fa a inovat\u00edvnu alternat\u00edvnu lie\u010dbu PCOS<\/strong>. Predbe\u017en\u00e9 \u00fadaje zo \u0161t\u00fadie PCOS s viaczlo\u017ekov\u00fdm probiotikom<\/strong> v kombin\u00e1cii s vitam\u00ednom D<\/strong><\/span><\/a> u\u017e uk\u00e1zali, \u017ee probiotikum<\/strong> \u0161pecifick\u00e9 pre dan\u00fa indik\u00e1ciu je dobre tolerovan\u00e9, preto\u017ee pom\u00e1ha aj pri budovan\u00ed zdravej \u010drevnej mikrobioty<\/strong><\/span><\/a>.<\/p>

Okrem toho sa uk\u00e1zalo, \u017ee probiotik\u00e1<\/strong> s\u00fa obzvl\u00e1\u0161\u0165 \u00fa\u010dinn\u00e9 u \u013eud\u00ed s intoleranciou metform\u00ednu<\/strong>. A napokon, preuk\u00e1zate\u013ene pozit\u00edvny \u00fa\u010dinok<\/strong> sa prejavil najm\u00e4 na reprodukciu – \u010do je rozpoznate\u013en\u00e9 pod\u013ea toho, \u017ee v r\u00e1mci \u0161t\u00fadie sa u\u017e narodilo 6 det\u00ed<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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S\u00fa\u010dasn\u00e9 \u0161t\u00fadie: s\u00favislos\u0165 medzi mikrobi\u00f3mom & hormon\u00e1lnym syst\u00e9mom<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Okrem toho existuje cel\u00fd rad nov\u00fdch \u0161t\u00fadi\u00ed<\/strong>, ktor\u00e9 sk\u00famaj\u00fa s\u00favislosti<\/strong> medzi mikrobi\u00f3mom<\/strong> a hormon\u00e1lnym syst\u00e9mom<\/strong> na viacer\u00fdch \u00farovniach. Tieto \u0161t\u00fadie tie\u017e poukazuj\u00fa na v\u00fdznam mikrobi\u00f3mu<\/strong> pre reprodukciu a energetick\u00fd metabolizmus<\/strong>.<\/p>

Doteraz sa predpokladalo, \u017ee kosti, svaly, \u017e\u013eazy, pe\u010de\u0148 a \u010drev\u00e1 funguj\u00fa samy o sebe. Telo je v\u0161ak syst\u00e9m, v ktorom sa v\u0161etky org\u00e1ny navz\u00e1jom ovplyv\u0148uj\u00fa<\/strong>. Napr\u00edklad potrebujeme butyr\u00e1t<\/strong> (kyselinu maslov\u00fa)<\/strong>, ktor\u00fd produkuje \u010drevn\u00fd mikrobi\u00f3m, aby bol plne funk\u010dn\u00fd parathorm\u00f3n<\/strong>, ktor\u00fd buduje kosti.<\/p>

Univ.-Prof. Dr. Obermayer-Pietsch na z\u00e1ver informovala o klinickej \u0161t\u00fadii s viacdruhov\u00fdm probiotikom<\/strong><\/span><\/a> u transsexu\u00e1lnych \u017eien<\/strong>, v ktorej sa uk\u00e1zalo, \u017ee toto peror\u00e1lne po\u017eit\u00e9 probiotikum<\/strong><\/span><\/a> pre\u017eije prechod \u010drevom, kolonizuje tr\u00e1viaci trakt<\/strong> a odtia\u013e \u00faspe\u0161ne kolonizuje sliznicu po\u0161vy<\/strong>. \u010eal\u0161ie \u00fadaje o mikrobi\u00f3me tie\u017e uk\u00e1zali, \u017ee mikrobi\u00f3m m\u00e1 z\u00e1sadn\u00fd vplyv na psychiku<\/strong>. V s\u00falade s t\u00fdm sa v Grazi uskuto\u010d\u0148uje v\u00fdskum zameran\u00fd na v\u00fdvoj takzvan\u00fdch „psychobiot\u00edk“<\/strong><\/span><\/a>, \u010do s\u00fa probiotik\u00e1<\/strong><\/span><\/a>, ktor\u00e9 maj\u00fa jasn\u00fd pr\u00ednos pre pozit\u00edvny vplyv na psychiku \u010dloveka<\/strong>.<\/p>

Univ.-Prof. Dr. Obermayer-Pietsch napokon zd\u00f4raznila, \u017ee pri posudzovan\u00ed vz\u0165ahu medzi horm\u00f3nmi<\/strong> a metabolizmom<\/strong> je obzvl\u00e1\u0161\u0165 d\u00f4le\u017eit\u00e9 zahrn\u00fa\u0165 \u010do najviac ovplyv\u0148uj\u00facich faktorov, ako napr\u00edklad typ stravy<\/strong>, \u010di u\u017e ide o stravu s vysok\u00fdm obsahom vl\u00e1kniny<\/strong><\/span><\/a>, vegetari\u00e1nsku alebo m\u00e4sit\u00fa, zlo\u017eenie \u010drevnej mikrobioty <\/strong>v z\u00e1vislosti od nej, ako aj \u010fal\u0161ie podmienky prostredia, napr\u00edklad pracovn\u00fd stres<\/strong><\/span><\/a> a psychick\u00e9 pre\u0165a\u017eenie<\/strong>. Pri pou\u017e\u00edvan\u00ed probiotick\u00fdch intervenci\u00ed je hlavn\u00fdm cie\u013eom sk\u00fama\u0165, ako r\u00f4zne bakteri\u00e1lne kmene ovplyv\u0148uj\u00fa<\/strong> \u00fa\u010dastn\u00edkov \u0161t\u00fadie, aby sa v kone\u010dnom d\u00f4sledku zaviedla „personalizovan\u00e1 medic\u00edna“<\/strong>, ktor\u00e1 zah\u0155\u0148a v\u0161etky nov\u00e9 poznatky o rozmanit\u00fdch vz\u0165ahoch<\/strong> medzi \u010dlovekom<\/strong> a mikr\u00f3bmi<\/strong><\/span><\/a>.<\/p>

Cel\u00fd rozhovor (v nem\u010dine) n\u00e1jdete tu: > k rozhovoru<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Univ.-Prof. Dr. Barbara Obermayer-Pietsch je odborn\u00ed\u010dkou na endokrinol\u00f3giu a diabetol\u00f3giu na Lek\u00e1rskej univerzite v Grazi a vedie tam ve\u013ek\u00e9 endokrinologick\u00e9 laborat\u00f3rium. Spolu so svoj\u00edm t\u00edmom sk\u00fama komplexn\u00e9 syst\u00e9mov\u00e9 interakcie medzi kos\u0165ami, mikrobi\u00f3mom, horm\u00f3nmi a metabolizmom inzul\u00ednu, ako aj mo\u017enosti v\u00fdvoja \u0161peci\u00e1lnych biomarkerov na prevenciu r\u00f4znych ochoren\u00ed. V rozhovore na t\u00e9mu „Je plodnos\u0165 v \u010drev\u00e1ch?“, ktor\u00fd je uverejnen\u00fd v aktu\u00e1lnom \u010d\u00edsle \u010dasopisu PERISKOP z decembra 2023, sa m\u00f4\u017eete po prv\u00fdkr\u00e1t dozvedie\u0165 viac o podrobnostiach jej v\u00fdskumu.<\/p>\n","protected":false},"author":17,"featured_media":22058,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[47,85],"tags":[],"class_list":["post-22044","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-institut-allergosan","category-novinky-vo-vyskume"],"acf":[],"rank_math":{"og:title":"Plodnos\u0165 a s\u00favislos\u0165 s mikrobi\u00f3mom - OMNi-BiOTiC\u00ae","og:desc":"Ak\u00e1 je s\u00favislos\u0165 medzi mikrobi\u00f3mom, plodnos\u0165ou a hormon\u00e1lnym syst\u00e9mom? A ak\u00e9 s\u00fa mo\u017enosti lie\u010dby PCOS - polycistick\u00fdch vaje\u010dn\u00edkov?","og:url":"https:\/\/www.omni-biotic.com\/sk-sk\/blog\/plodnost-a-suvislost-s-mikrobiomom\/","og:locale":"sk_SK","og:image":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-content\/uploads\/sites\/9\/2024\/01\/PCOS.png","og:image:width":"700","og:image:height":"500"},"additional_data":{"thumbnail":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-content\/uploads\/sites\/9\/2024\/01\/PCOS.png"},"blog_info":{"country":"sk-sk"},"_links":{"self":[{"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/posts\/22044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/comments?post=22044"}],"version-history":[{"count":7,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/posts\/22044\/revisions"}],"predecessor-version":[{"id":28631,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/posts\/22044\/revisions\/28631"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/media\/22058"}],"wp:attachment":[{"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/media?parent=22044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/categories?post=22044"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.omni-biotic.com\/sk-sk\/wp-json\/wp\/v2\/tags?post=22044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}